Neuro-glial interactions at the nodes of Ranvier: implication in health and diseases
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Neuro-glial interactions at the nodes of Ranvier: implication in health and diseases
Specific cell adhesion molecules (CAMs) are dedicated to the formation of axo-glial contacts at the nodes of Ranvier of myelinated axons. They play a central role in the organization and maintenance of the axonal domains: the node, paranode, and juxtaparanode. In particular, CAMs are essential for the accumulation of voltage-gated sodium channels at the nodal gap that ensures the rapid and salt...
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Glycoprotein M6B and the closely related proteolipid protein regulate oligodendrocyte myelination in the central nervous system, but their role in the peripheral nervous system is less clear. Here we report that M6B is located at nodes of Ranvier in peripheral nerves where it stabilizes the nodal axolemma. We show that M6B is co-localized and associates with gliomedin at Schwann cell microvilli...
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15 صفحه اولThe paranodal cytoskeleton clusters Na+ channels at nodes of Ranvier
A high density of Na+ channels at nodes of Ranvier is necessary for rapid and efficient action potential propagation in myelinated axons. Na+ channel clustering is thought to depend on two axonal cell adhesion molecules that mediate interactions between the axon and myelinating glia at the nodal gap (i.e., NF186) and the paranodal junction (i.e., Caspr). Here we show that while Na+ channels clu...
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ژورنال
عنوان ژورنال: Frontiers in Cellular Neuroscience
سال: 2013
ISSN: 1662-5102
DOI: 10.3389/fncel.2013.00196